MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development

Background: 46,XY disorders/differences of sex development (46,XY DSD) are congenital conditions that result from abnormal gonadal development (gonadal dysgenesis) or abnormalities in androgen synthesis or action. During early embryonic development, several genes are involved in regulating the initi...

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Detalles Bibliográficos
Autores principales: Chen, Hong, Chen, Qingqing, Zhu, Yilin, Yuan, Ke, Li, Huizhu, Zhang, Bingtao, Jia, Zexiao, Zhou, Hui, Fan, Mingjie, Qiu, Yue, Zhuang, Qianqian, Lei, Zhaoying, Li, Mengyao, Huang, Wendong, Liang, Li, Yan, Qingfeng, Wang, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927045/
https://www.ncbi.nlm.nih.gov/pubmed/35309143
http://dx.doi.org/10.3389/fgene.2022.736988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927045/
https://www.ncbi.nlm.nih.gov/pubmed/35309143
http://dx.doi.org/10.3389/fgene.2022.736988

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