Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase

The Dbf4-dependent kinase Cdc7 (DDK) regulates DNA replication initiation by phosphorylation of the MCM double hexamer (MCM-DH) to promote helicase activation. Here, we determine a series of cryo electron microscopy (cryo-EM) structures of yeast DDK bound to the MCM-DH. These structures, occupied by...

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Detalles Bibliográficos
Autores principales: Cheng, Jiaxuan, Li, Ningning, Huo, Yunjing, Dang, Shangyu, Tye, Bik-Kwoon, Gao, Ning, Zhai, Yuanliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927117/
https://www.ncbi.nlm.nih.gov/pubmed/35296675
http://dx.doi.org/10.1038/s41467-022-29070-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927117/
https://www.ncbi.nlm.nih.gov/pubmed/35296675
http://dx.doi.org/10.1038/s41467-022-29070-5

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