Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression

ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS, iSAFE and F(ST) statistics, we identified regulatory acting variants affecting ALDH2 gene expression under positive selection in populations of European ancestry. Several SNPs (rs3184504, rs4766578...

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Detalles Bibliográficos
Autores principales: Schaschl, Helmut, Göllner, Tobias, Morris, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927298/
https://www.ncbi.nlm.nih.gov/pubmed/35296751
http://dx.doi.org/10.1038/s41598-022-08588-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927298/
https://www.ncbi.nlm.nih.gov/pubmed/35296751
http://dx.doi.org/10.1038/s41598-022-08588-0

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