Cargando…

Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression

ALDH2 is a key enzyme in alcohol metabolism that protects cells from acetaldehyde toxicity. Using iHS, iSAFE and F(ST) statistics, we identified regulatory acting variants affecting ALDH2 gene expression under positive selection in populations of European ancestry. Several SNPs (rs3184504, rs4766578...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schaschl, Helmut, Göllner, Tobias, Morris, David L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927298/ https://www.ncbi.nlm.nih.gov/pubmed/35296751 http://dx.doi.org/10.1038/s41598-022-08588-0

Ejemplares similares

Author Correction: Positive selection acts on regulatory genetic variants in populations of European ancestry that affect ALDH2 gene expression
por: Schaschl, Helmut, et al.
Publicado: (2023)

Unveiling the Genetic History of the Maniq, a Primary Hunter-Gatherer Society
por: Göllner, Tobias, et al.
Publicado: (2022)

Cis-Regulatory Variants Affect CHRNA5 mRNA Expression in Populations of African and European Ancestry
por: Wang, Jen-Chyong, et al.
Publicado: (2013)

Population-specific, recent positive directional selection suggests adaptation of human male reproductive genes to different environmental conditions
por: Schaschl, Helmut, et al.
Publicado: (2020)

Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes
por: Schaschl, Helmut, et al.
Publicado: (2015)

Generalization and fine mapping of European ancestry-based central adiposity variants in African ancestry populations
por: Yoneyama, Sachiko, et al.
Publicado: (2016)

Two genetic variants explain the association of European ancestry with multiple sclerosis risk in African-Americans
por: Nakatsuka, Nathan, et al.
Publicado: (2020)

Variants in BANK1 are associated with lupus nephritis of European ancestry
por: Bolin, Karin, et al.
Publicado: (2021)

Discerning the Ancestry of European Americans in Genetic Association Studies
por: Price, Alkes L, et al.
Publicado: (2008)

Positive selection on two mitochondrial coding genes and adaptation signals in hares (genus Lepus) from China
por: Awadi, Asma, et al.
Publicado: (2021)

Tracing Jomon and Yayoi ancestries in Japan using ALDH2 and JC virus genotype distributions
por: Miyamori, Daisuke, et al.
Publicado: (2015)

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
por: Benjamin, Emelia J., et al.
Publicado: (2009)

Sex differences in the genetics of sarcoidosis across European and African ancestry populations
por: Xiong, Ying, et al.
Publicado: (2023)

Analysis of potential protein-modifying variants in 9000 endometriosis patients and 150000 controls of European ancestry
por: Sapkota, Yadav, et al.
Publicado: (2017)

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
por: Allen, Richard J, et al.
Publicado: (2017)

Sex-specific selection for MHC variability in Alpine chamois
por: Schaschl, Helmut, et al.
Publicado: (2012)

HLA class II sequence variants influence tuberculosis risk in populations of European ancestry
por: Sveinbjornsson, Gardar, et al.
Publicado: (2016)

Genetic Population Structure Analysis in New Hampshire Reveals Eastern European Ancestry
por: Sloan, Chantel D., et al.
Publicado: (2009)

The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States
por: Bryc, Katarzyna, et al.
Publicado: (2015)

Genetic ancestry changes in Stone to Bronze Age transition in the East European plain
por: Saag, Lehti, et al.
Publicado: (2021)

The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations
por: Wang, Zhe, et al.
Publicado: (2022)

Exome-Wide Association Study Reveals Host Genetic Variants Likely Associated with the Severity of COVID-19 in Patients of European Ancestry
por: Upadhyai, Priyanka, et al.
Publicado: (2022)

Ancestry-associated transcriptomic profiles of breast cancer in patients of African, Arab, and European ancestry
por: Roelands, Jessica, et al.
Publicado: (2021)

Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry
por: Blue, Elizabeth E., et al.
Publicado: (2020)

Molecular profiling of a real-world breast cancer cohort with genetically inferred ancestries reveals actionable tumor biology differences between European ancestry and African ancestry patient populations
por: Miyashita, Minoru, et al.
Publicado: (2023)

Genetic Ancestry Has the Same Major Problems as Phenotypic Ancestry
por: Burney, Peter
Publicado: (2022)

Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry
por: Schaeffeler, Elke, et al.
Publicado: (2019)

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
por: Pazoki, Raha, et al.
Publicado: (2021)

Genetics of Body Fat Distribution: Comparative Analyses in Populations with European, Asian and African Ancestries
por: Sun, Chang, et al.
Publicado: (2021)

Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry
por: Bateman, Nicholas W., et al.
Publicado: (2021)

A probable cis-acting genetic modifier of Huntington disease frequent in individuals with African ancestry
por: Dawson, Jessica, et al.
Publicado: (2022)

Human-Genetic Ancestry Inference and False Positives in Forensic Familial Searching
por: Fortier, Alyssa Lyn, et al.
Publicado: (2020)

Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer
por: Bobyn, Anna, et al.
Publicado: (2020)

Identifying genetic regulatory variants that affect transcription factor activity
por: Li, Xiaoting, et al.
Publicado: (2023)

The genetic architecture of temperature adaptation is shaped by population ancestry and not by selection regime
por: Otte, Kathrin A., et al.
Publicado: (2021)

Racial Differences in the Oral Microbiome: Data from Low-Income Populations of African Ancestry and European Ancestry
por: Yang, Yaohua, et al.
Publicado: (2019)

Enterolignan Production in a Flaxseed Intervention Study in Postmenopausal US Women of African Ancestry and European Ancestry
por: McCann, Susan E., et al.
Publicado: (2021)

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
por: Ge, Yan, et al.
Publicado: (2016)

Evolutionary genetics of MHC class II beta genes in the brown hare, Lepus europaeus
por: Smith, Steve, et al.
Publicado: (2011)

Admixture Mapping of Sepsis in European Individuals With African Ancestries
por: Hernandez-Beeftink, Tamara, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_24dimqbjv6d8e9heb3t43ii934