Cargando…

Machine learning discovery of missing links that mediate alternative branches to plant alkaloids

Engineering the microbial production of secondary metabolites is limited by the known reactions of correctly annotated enzymes. Therefore, the machine learning discovery of specialized enzymes offers great potential to expand the range of biosynthesis pathways. Benzylisoquinoline alkaloid production...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vavricka, Christopher J., Takahashi, Shunsuke, Watanabe, Naoki, Takenaka, Musashi, Matsuda, Mami, Yoshida, Takanobu, Suzuki, Ryo, Kiyota, Hiromasa, Li, Jianyong, Minami, Hiromichi, Ishii, Jun, Tsuge, Kenji, Araki, Michihiro, Kondo, Akihiko, Hasunuma, Tomohisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927377/ https://www.ncbi.nlm.nih.gov/pubmed/35296652 http://dx.doi.org/10.1038/s41467-022-28883-8

Ejemplares similares

Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
por: Vavricka, Christopher J., et al.
Publicado: (2019)

Author Correction: Mechanism-based tuning of insect 3,4-dihydroxyphenylacetaldehyde synthase for synthetic bioproduction of benzylisoquinoline alkaloids
por: Vavricka, Christopher J., et al.
Publicado: (2019)

Synthesis of Sulfo-Sialic Acid Analogues: Potent Neuraminidase Inhibitors in Regards to Anomeric Functionality
por: Vavricka, Christopher J., et al.
Publicado: (2017)

Improved sugar-free succinate production by Synechocystis sp. PCC 6803 following identification of the limiting steps in glycogen catabolism
por: Hasunuma, Tomohisa, et al.
Publicado: (2016)

Nitrogen Availability Affects the Metabolic Profile in Cyanobacteria
por: Inabe, Kosuke, et al.
Publicado: (2021)

A Systematic Approach to Time-series Metabolite Profiling and RNA-seq Analysis of Chinese Hamster Ovary Cell Culture
por: Hsu, Han-Hsiu, et al.
Publicado: (2017)

Widespread effect of N-acetyl-d-glucosamine assimilation on the metabolisms of amino acids, purines, and pyrimidines in Scheffersomyces stipitis
por: Inokuma, Kentaro, et al.
Publicado: (2018)

Resveratrol production from several types of saccharide sources by a recombinant Scheffersomyces stipitis strain
por: Kobayashi, Yuma, et al.
Publicado: (2021)

Development of bio-based fine chemical production through synthetic bioengineering
por: Hara, Kiyotaka Y, et al.
Publicado: (2014)

Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme
por: Kato, Yuichi, et al.
Publicado: (2021)

Day/Night Separation of Oxygenic Energy Metabolism and Nuclear DNA Replication in the Unicellular Red Alga Cyanidioschyzon merolae
por: Miyagishima, Shin-ya, et al.
Publicado: (2019)

Dynamic metabolic profiling of cyanobacterial glycogen biosynthesis under conditions of nitrate depletion
por: Hasunuma, Tomohisa, et al.
Publicado: (2013)

Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content
por: Sasaki, Kengo, et al.
Publicado: (2015)

Light/dark cycling causes delayed lipid accumulation and increased photoperiod-based biomass yield by altering metabolic flux in oleaginous Chlamydomonas sp.
por: Kato, Yuichi, et al.
Publicado: (2019)

Direct production of organic acids from starch by cell surface-engineered Corynebacterium glutamicum in anaerobic conditions
por: Tsuge, Yota, et al.
Publicado: (2013)

Aromatic secondary metabolite production from glycerol was enhanced by amino acid addition in Pichia pastoris
por: Kumokita, Ryota, et al.
Publicado: (2023)

Overexpression of flv3 improves photosynthesis in the cyanobacterium Synechocystis sp. PCC6803 by enhancement of alternative electron flow
por: Hasunuma, Tomohisa, et al.
Publicado: (2014)

Development of a stable semi-continuous lipid production system of an oleaginous Chlamydomonas sp. mutant using multi-omics profiling
por: Oyama, Tomoki, et al.
Publicado: (2022)

Evaluation of genes involved in oxidative phosphorylation in yeast by developing a simple and rapid method to measure mitochondrial ATP synthetic activity
por: Ye, Xiaoting, et al.
Publicado: (2015)

Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases
por: Isogai, Shota, et al.
Publicado: (2021)

Increased biomass production and glycogen accumulation in apcE gene deleted Synechocystis sp. PCC 6803
por: Joseph, Ancy, et al.
Publicado: (2014)

Metabolic pathway engineering based on metabolomics confers acetic and formic acid tolerance to a recombinant xylose-fermenting strain of Saccharomyces cerevisiae
por: Hasunuma, Tomohisa, et al.
Publicado: (2011)

Efficient yeast cell-surface display of exo- and endo-cellulase using the SED1 anchoring region and its original promoter
por: Inokuma, Kentaro, et al.
Publicado: (2014)

Disruption of PHO13 improves ethanol production via the xylose isomerase pathway
por: Bamba, Takahiro, et al.
Publicado: (2016)

Ethanol production from N-acetyl-d-glucosamine by Scheffersomyces stipitis strains
por: Inokuma, Kentaro, et al.
Publicado: (2016)

Complete Genome Sequence of Kluyveromyces marxianus NBRC1777, a Nonconventional Thermotolerant Yeast
por: Inokuma, Kentaro, et al.
Publicado: (2015)

Erratum for Inokuma et al., Complete Genome Sequence of Kluyveromyces marxianus NBRC1777, a Nonconventional Thermotolerant Yeast
por: Inokuma, Kentaro, et al.
Publicado: (2017)

Increased flux in acetyl-CoA synthetic pathway and TCA cycle of Kluyveromyces marxianus under respiratory conditions
por: Sakihama, Yuri, et al.
Publicado: (2019)

A bacterial platform for fermentative production of plant alkaloids
por: Nakagawa, Akira, et al.
Publicado: (2011)

Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)
por: Kudo, Hirotaka, et al.
Publicado: (2023)

Derivation of the multiply‐branched ergot alkaloid pathway of fungi
por: Panaccione, Daniel G.
Publicado: (2023)

Avoiding entry into intracellular protein degradation pathways by signal mutations increases protein secretion in Pichia pastoris
por: Ito, Yoichiro, et al.
Publicado: (2022)

Genetic and physiological basis for antibody production by Kluyveromyces marxianus
por: Nambu-Nishida, Yumiko, et al.
Publicado: (2018)

Development of a comprehensive set of tools for genome engineering in a cold- and thermo-tolerant Kluyveromyces marxianus yeast strain
por: Nambu-Nishida, Yumiko, et al.
Publicado: (2017)

Anatomical liver segmentectomy 2 for combined hepatocellular carcinoma and cholangiocarcinoma with tumor thrombus in segment 2 portal branch
por: Ishii, Hiromichi, et al.
Publicado: (2012)

Erratum: A bacterial platform for fermentative production of plant alkaloids
por: Nakagawa, Akira, et al.
Publicado: (2012)

Improvement of Xylose Fermentation Ability under Heat and Acid Co-Stress in Saccharomyces cerevisiae Using Genome Shuffling Technique
por: Inokuma, Kentaro, et al.
Publicado: (2017)

Pulsed-Ultrasound Irradiation Induces the Production of Itaconate and Attenuates Inflammatory Responses in Macrophages
por: Yamaguchi, Atomu, et al.
Publicado: (2022)

Microbial production of novel sulphated alkaloids for drug discovery
por: Matsumura, Eitaro, et al.
Publicado: (2018)

Enzymatic improvement of mitochondrial thiol oxidase Erv1 for oxidized glutathione fermentation by Saccharomyces cerevisiae
por: Kobayashi, Jyumpei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_i3i2emj8993q9ul5jbn5dqqefh