Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver

Non-alcoholic steatohepatitis (NASH) is a most common chronic liver disease that is manifested by steatosis, inflammation, fibrosis, and tissue damage. Hepatocytes produce giant mitochondria termed megamitochondria in patients with NASH. It has been shown that gene knockout of OPA1, a mitochondrial...

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Detalles Bibliográficos
Autores principales: Yamada, Tatsuya, Murata, Daisuke, Kleiner, David E., Anders, Robert, Rosenberg, Avi Z., Kaplan, Jeffrey, Hamilton, James P., Aghajan, Mariam, Levi, Moshe, Wang, Nae-Yuh, Dawson, Ted M., Yanagawa, Toru, Powers, Andrew F., Iijima, Miho, Sesaki, Hiromi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927900/
https://www.ncbi.nlm.nih.gov/pubmed/35310936
http://dx.doi.org/10.1016/j.isci.2022.103996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927900/
https://www.ncbi.nlm.nih.gov/pubmed/35310936
http://dx.doi.org/10.1016/j.isci.2022.103996

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