Cataract-linked serine mutations in the gap junction protein connexin50 expose a sorting signal that promotes its lysosomal degradation

Many human connexin50 (Cx50) mutants have been linked to cataracts including two carboxyl terminus serine mutants that are known phosphorylation sites in the lens (Cx50S258F and Cx50S259Y). To examine the behavior of these mutants and the role of phosphorylation at these positions, we stably transfe...

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Detalles Bibliográficos
Autores principales: Minogue, Peter J., Tong, Jun-Jie, Wichmann, Kelly, Mysliwiec, Hubert, Ebihara, Lisa, Beyer, Eric C., Berthoud, Viviana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927986/
https://www.ncbi.nlm.nih.gov/pubmed/35120923
http://dx.doi.org/10.1016/j.jbc.2022.101673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8927986/
https://www.ncbi.nlm.nih.gov/pubmed/35120923
http://dx.doi.org/10.1016/j.jbc.2022.101673

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