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Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment

INTRODUCTION: The underlying pathophysiology of slight cognitive dysfunction in Parkinson’s disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MC...

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Autores principales: Mano, Tomoo, Kinugawa, Kaoru, Ozaki, Maki, Kataoka, Hiroshi, Sugie, Kazuma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928128/
https://www.ncbi.nlm.nih.gov/pubmed/35308256
http://dx.doi.org/10.1016/j.prdoa.2022.100140
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author Mano, Tomoo
Kinugawa, Kaoru
Ozaki, Maki
Kataoka, Hiroshi
Sugie, Kazuma
author_facet Mano, Tomoo
Kinugawa, Kaoru
Ozaki, Maki
Kataoka, Hiroshi
Sugie, Kazuma
author_sort Mano, Tomoo
collection PubMed
description INTRODUCTION: The underlying pathophysiology of slight cognitive dysfunction in Parkinson’s disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MCI. METHODS: Twenty patients with sporadic PD-MCI were evaluated for FC in the brain network. Further, electroencephalography (EEG) coherence analysis in the whole-brain and quantified regional coherence using phase coupling were performed for each frequency, and motor and cognitive function were assessed in the whole-brain. RESULTS: The degree of cognitive impairment was related to a decrease in the coherence in the alpha ranges. The regional coherence in the left frontal-left parietal region rather than the right frontal-right parietal region showed a higher correlation with the cognitive function scores. CONCLUSION: The differences in EEG coherence across different types of cognitive dysfunction reflect a compensatory response to the heterogeneous and complex clinical presentation of PD-MCI. Our findings indicate decreased brain efficiency and impaired neural synchronization in PD-MCI; these results may be crucial in elucidating the pathological exacerbation of PD-MCI.
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spelling pubmed-89281282022-03-18 Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment Mano, Tomoo Kinugawa, Kaoru Ozaki, Maki Kataoka, Hiroshi Sugie, Kazuma Clin Park Relat Disord Short Communication INTRODUCTION: The underlying pathophysiology of slight cognitive dysfunction in Parkinson’s disease-related mild cognitive impairment (PD-MCI) is yet to be elucidated. Our study aimed to evaluate the association between cognitive function and brain functional connectivity (FC) in patients with PD-MCI. METHODS: Twenty patients with sporadic PD-MCI were evaluated for FC in the brain network. Further, electroencephalography (EEG) coherence analysis in the whole-brain and quantified regional coherence using phase coupling were performed for each frequency, and motor and cognitive function were assessed in the whole-brain. RESULTS: The degree of cognitive impairment was related to a decrease in the coherence in the alpha ranges. The regional coherence in the left frontal-left parietal region rather than the right frontal-right parietal region showed a higher correlation with the cognitive function scores. CONCLUSION: The differences in EEG coherence across different types of cognitive dysfunction reflect a compensatory response to the heterogeneous and complex clinical presentation of PD-MCI. Our findings indicate decreased brain efficiency and impaired neural synchronization in PD-MCI; these results may be crucial in elucidating the pathological exacerbation of PD-MCI. Elsevier 2022-03-10 /pmc/articles/PMC8928128/ /pubmed/35308256 http://dx.doi.org/10.1016/j.prdoa.2022.100140 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Mano, Tomoo
Kinugawa, Kaoru
Ozaki, Maki
Kataoka, Hiroshi
Sugie, Kazuma
Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title_full Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title_fullStr Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title_full_unstemmed Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title_short Neural synchronization analysis of electroencephalography coherence in patients with Parkinson’s disease-related mild cognitive impairment
title_sort neural synchronization analysis of electroencephalography coherence in patients with parkinson’s disease-related mild cognitive impairment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928128/
https://www.ncbi.nlm.nih.gov/pubmed/35308256
http://dx.doi.org/10.1016/j.prdoa.2022.100140
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