Failure Of Hearing Acquisition in Mice With Reduced Expression of Connexin 26 Correlates With the Abnormal Phasing of Apoptosis Relative to Autophagy and Defective ATP-Dependent Ca(2+) Signaling in Kölliker’s Organ

Mutations in the GJB2 gene that encodes connexin 26 (Cx26) are the predominant cause of prelingual hereditary deafness, and the most frequently encountered variants cause complete loss of protein function. To investigate how Cx26 deficiency induces deafness, we examined the levels of apoptosis and a...

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Detalles Bibliográficos
Autores principales: Sun, Lianhua, Gao, Dekun, Chen, Junmin, Hou, Shule, Li, Yue, Huang, Yuyu, Mammano, Fabio, Chen, Jianyong, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928193/
https://www.ncbi.nlm.nih.gov/pubmed/35308122
http://dx.doi.org/10.3389/fncel.2022.816079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928193/
https://www.ncbi.nlm.nih.gov/pubmed/35308122
http://dx.doi.org/10.3389/fncel.2022.816079

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