Modulation of Glucose Production by Central Insulin Requires IGF-1 Receptors in AgRP Neurons

Similar to insulin, central administration of IGF-1 can suppress hepatic glucose production (HGP), but it is unclear whether this effect is mediated via insulin receptors (InsRs) or IGF-1 receptors (IGF-1Rs) in the brain. To this end, we used pharmacologic and genetic approaches in combination with...

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Detalles Bibliográficos
Autores principales: Farias Quipildor, Gabriela, Mao, Kai, Beltran, Pedro J., Barzilai, Nir, Huffman, Derek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2021
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928909/
https://www.ncbi.nlm.nih.gov/pubmed/34285117
http://dx.doi.org/10.2337/db21-0028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8928909/
https://www.ncbi.nlm.nih.gov/pubmed/34285117
http://dx.doi.org/10.2337/db21-0028

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