Lessons from a Single Amino Acid Substitution: Anticancer and Antibacterial Properties of Two Phospholipase A(2)-Derived Peptides

The membrane-active nature of phospholipase A(2)-derived peptides makes them potential candidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragments taken from snake venom Lys49-PLA(2) toxins (p-AppK and p-Acl), differing by a leucine/phenylalanine substitution, we...

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Detalles Bibliográficos
Autores principales: Almeida, José R., Mendes, Bruno, Lancellotti, Marcelo, Franchi, Gilberto C., Passos, Óscar, Ramos, Maria J., Fernandes, Pedro A., Alves, Cláudia, Vale, Nuno, Gomes, Paula, da Silva, Saulo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929095/
https://www.ncbi.nlm.nih.gov/pubmed/35723383
http://dx.doi.org/10.3390/cimb44010004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929095/
https://www.ncbi.nlm.nih.gov/pubmed/35723383
http://dx.doi.org/10.3390/cimb44010004

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