Metopimazine is primarily metabolized by a liver amidase in humans

Metopimazine (MPZ) is a peripherally restricted, dopamine D2 receptor antagonist used for four decades to treat acute nausea and vomiting. MPZ is currently under clinical investigation for the treatment of gastroparesis (GP). MPZ undergoes high first‐pass metabolism that produces metopimazine acid (...

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Detalles Bibliográficos
Autores principales: Busby, Robert W., Cai, Xiaokun, Yang, Sihyung, Ramos, Luis, Venkatarangan, Lata, Shen, Helen, Wax, Stephen, Sadeque, Abu J. M., De Colle, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929364/
https://www.ncbi.nlm.nih.gov/pubmed/34918875
http://dx.doi.org/10.1002/prp2.903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929364/
https://www.ncbi.nlm.nih.gov/pubmed/34918875
http://dx.doi.org/10.1002/prp2.903

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