Quantitation of Diclofenac, Tolbutamide, and Warfarin as Typical CYP2C9 Substrates in Rat Plasma by UPLC-MS/MS and Its Application to Evaluate Linderane-Mediated Herb-Drug Interactions

Linderane (LDR), the main active and distinctive component of L. aggregate, is a mechanism-based inactivator of CYP2C9 in vitro, indicating the occurrence of herb-drug interactions. However, little is known about the changes of the pharmacokinetic properties of the common clinical drugs as CYP2C9 su...

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Detalles Bibliográficos
Autores principales: Zhang, Tingting, Peng, Ting, Rao, Jinqiu, Wang, Kai, Qiu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930270/
https://www.ncbi.nlm.nih.gov/pubmed/35309717
http://dx.doi.org/10.1155/2022/1900037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930270/
https://www.ncbi.nlm.nih.gov/pubmed/35309717
http://dx.doi.org/10.1155/2022/1900037

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