Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH

Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy...

Descripción completa

Detalles Bibliográficos
Autores principales: Stsiapanava, Alena, Xu, Chenrui, Nishio, Shunsuke, Han, Ling, Yamakawa, Nao, Carroni, Marta, Tunyasuvunakool, Kathryn, Jumper, John, de Sanctis, Daniele, Wu, Bin, Jovine, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930769/
https://www.ncbi.nlm.nih.gov/pubmed/35273390
http://dx.doi.org/10.1038/s41594-022-00729-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930769/
https://www.ncbi.nlm.nih.gov/pubmed/35273390
http://dx.doi.org/10.1038/s41594-022-00729-3

Ejemplares similares