Cargando…

Seipin forms a flexible cage at lipid droplet formation sites

Lipid droplets (LDs) form in the endoplasmic reticulum by phase separation of neutral lipids. This process is facilitated by the seipin protein complex, which consists of a ring of seipin monomers, with a yet unclear function. Here, we report a structure of S. cerevisiae seipin based on cryogenic-el...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arlt, Henning, Sui, Xuewu, Folger, Brayden, Adams, Carson, Chen, Xiao, Remme, Roman, Hamprecht, Fred A., DiMaio, Frank, Liao, Maofu, Goodman, Joel M., Farese, Robert V., Walther, Tobias C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930772/ https://www.ncbi.nlm.nih.gov/pubmed/35210614 http://dx.doi.org/10.1038/s41594-021-00718-y

Ejemplares similares

Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
por: Sui, Xuewu, et al.
Publicado: (2018)

Seipin transmembrane segments critically function in triglyceride nucleation and lipid droplet budding from the membrane
por: Kim, Siyoung, et al.
Publicado: (2022)

Seipin is required for converting nascent to mature lipid droplets
por: Wang, Huajin, et al.
Publicado: (2016)

Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology
por: Cartwright, Bethany R., et al.
Publicado: (2015)

Seipin regulates ER–lipid droplet contacts and cargo delivery
por: Salo, Veijo T, et al.
Publicado: (2016)

Retinyl esters form lipid droplets independently of triacylglycerol and seipin
por: Molenaar, Martijn R., et al.
Publicado: (2021)

Seipin regulates the formation of nuclear lipid droplets from a distance
por: Du, Ximing, et al.
Publicado: (2020)

LDIP cooperates with SEIPIN and LDAP to facilitate lipid droplet biogenesis in Arabidopsis
por: Pyc, Michal, et al.
Publicado: (2021)

Structure and catalytic mechanism of a human triglyceride synthesis enzyme
por: Sui, Xuewu, et al.
Publicado: (2020)

Tissue-Autonomous Function of Drosophila Seipin in Preventing Ectopic Lipid Droplet Formation
por: Tian, Yuan, et al.
Publicado: (2011)

Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation
por: Eisenberg-Bord, Michal, et al.
Publicado: (2018)

Wrapping up the fats—a structure of the lipid droplet biogenesis protein seipin
por: Bohnert, Maria
Publicado: (2018)

SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis
por: Jin, Yi, et al.
Publicado: (2020)

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells
por: Jayson, Christina B. K., et al.
Publicado: (2018)

Nuclear lipid droplets form in the inner nuclear membrane in a seipin-independent manner
por: Sołtysik, Kamil, et al.
Publicado: (2020)

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
por: Klug, Yoel A., et al.
Publicado: (2021)

Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis
por: Sui, Xuewu, et al.
Publicado: (2023)

Lipid droplets go nuclear
por: Farese, Robert V., et al.
Publicado: (2016)

The seipin complex Fld1/Ldb16 stabilizes ER–lipid droplet contact sites
por: Grippa, Alexandra, et al.
Publicado: (2015)

Seipin and Nem1 establish discrete ER subdomains to initiate yeast lipid droplet biogenesis
por: Choudhary, Vineet, et al.
Publicado: (2020)

Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain
por: Cao, Zhe, et al.
Publicado: (2019)

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast
por: Fei, Weihua, et al.
Publicado: (2008)

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase
por: Pagac, Martin, et al.
Publicado: (2016)

Balancing the fat: lipid droplets and human disease
por: Krahmer, Natalie, et al.
Publicado: (2013)

Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization
por: Shen, Wen-Jun, et al.
Publicado: (2022)

Seipin—still a mysterious protein?
por: Salo, Veijo T.
Publicado: (2023)

Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p
por: Han, Sungwon, et al.
Publicado: (2015)

The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification
por: Wang, Kun, et al.
Publicado: (2023)

Exploring Seipin: From Biochemistry to Bioinformatics Predictions
por: Craveiro Sarmento, Aquiles Sales, et al.
Publicado: (2018)

Promethin Is a Conserved Seipin Partner Protein
por: Castro, Inês G., et al.
Publicado: (2019)

Conditional targeting of phosphatidylserine decarboxylase to lipid droplets
por: Kumar, Santosh, et al.
Publicado: (2021)

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis
por: Chitraju, Chandramohan, et al.
Publicado: (2020)

Towards a mechanistic understanding of lipodystrophy and seipin functions
por: Wee, Kenneth, et al.
Publicado: (2014)

Role of Seipin in Human Diseases and Experimental Animal Models
por: Li, Yuying, et al.
Publicado: (2022)

Suppression of Adipogenesis by Pathogenic Seipin Mutant Is Associated with Inflammatory Response
por: Qiu, Wenjie, et al.
Publicado: (2013)

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
por: Bai, Bo, et al.
Publicado: (2019)

Seipin negatively regulates sphingolipid production at the ER–LD contact site
por: Su, Wei-Cheng, et al.
Publicado: (2019)

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane
por: Prasanna, Xavier, et al.
Publicado: (2021)

Structural Flexibility in Metal-Organic Cages
por: Martín Díaz, Andrés E., et al.
Publicado: (2021)

Deletion of Seipin Attenuates Vascular Function and the Anticontractile Effect of Perivascular Adipose Tissue
por: Wang, Mengyu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rt7mgm3ol1qq7p1916udg75s1j