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CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth

Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a treatment for Alzheimer’s disease and amyotrophic lateral scleros...

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Detalles Bibliográficos
Autores principales: Aghanoori, Mohamad-Reza, Agarwal, Prasoon, Gauvin, Evan, Nagalingam, Raghu S., Bonomo, Raiza, Yathindranath, Vinith, Smith, Darrell R., Hai, Yan, Lee, Samantha, Jolivalt, Corinne G., Calcutt, Nigel A., Jones, Meaghan J., Czubryt, Michael P., Miller, Donald W., Dolinsky, Vernon W., Mansuy-Aubert, Virginie, Fernyhough, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8930798/
https://www.ncbi.nlm.nih.gov/pubmed/35298717
http://dx.doi.org/10.1007/s00018-022-04201-9