Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model

Praliciguat is a soluble guanylate cyclase stimulator that elicits hemodynamic, anti-inflammatory, and antifibrotic effects in preclinical models of metabolic dysfunction. We assessed the metabolic effects of praliciguat in a mouse diet-induced obesity (DIO) model housed at thermoneutrality. At 6 we...

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Detalles Bibliográficos
Autores principales: Schwartzkopf, Chad D., Hadcock, John R., Liu, Guang, Germano, Peter, Roux, Julien, Shea, Courtney M., Buys, Emmanuel S., Jones, Juli E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931041/
https://www.ncbi.nlm.nih.gov/pubmed/35308230
http://dx.doi.org/10.3389/fphar.2022.852080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931041/
https://www.ncbi.nlm.nih.gov/pubmed/35308230
http://dx.doi.org/10.3389/fphar.2022.852080

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