Accurate positioning of functional residues with robotics-inspired computational protein design

Proteins achieve their complex functions, such as molecular recognition with high affinity and specificity, through intricate three-dimensional geometries in functional sites. To engineer new protein functions, accurate positioning of amino acid functional groups is therefore critical but has remain...

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Detalles Bibliográficos
Autores principales: Krivacic, Cody, Kundert, Kale, Pan, Xingjie, Pache, Roland A., Liu, Lin, Conchúir, Shane O, Jeliazkov, Jeliazko R., Gray, Jeffrey J., Thompson, Michael C., Fraser, James S., Kortemme, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931229/
https://www.ncbi.nlm.nih.gov/pubmed/35254891
http://dx.doi.org/10.1073/pnas.2115480119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931229/
https://www.ncbi.nlm.nih.gov/pubmed/35254891
http://dx.doi.org/10.1073/pnas.2115480119

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