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Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague
A recombinant enteric Yersinia pseudotuberculosis PB1(+) strain (Yptb) was designed to synthesize an adjuvant form of lipid A (monophosphoryl lipid A [MPLA]), and tailor an Asd(+) plasmid pSMV13 for high synthesis of the Yersinia pestis LcrV antigen. The recombinant Yptb mutant harboring the pSMV13...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931243/ https://www.ncbi.nlm.nih.gov/pubmed/35275791 http://dx.doi.org/10.1073/pnas.2109667119 |