Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

Neurodegenerative diseases affect a rapidly growing number of the aging population globally. These conditions have proven extremely difficult to treat due to our limited understanding of their mechanisms, but they are characterized by protein aggregation, inflammation, lysosomal dysfunction, and neu...

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Detalles Bibliográficos
Autores principales: Vest, Ryan T., Chou, Ching-Chieh, Zhang, Hui, Haney, Michael S., Li, Lulin, Laqtom, Nouf N., Chang, Betty, Shuken, Steven, Nguyen, Andy, Yerra, Lakshmi, Yang, Andrew C., Green, Carol, Tanga, Mary, Abu-Remaileh, Monther, Bassik, Michael C., Frydman, Judith, Luo, Jian, Wyss-Coray, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931323/
https://www.ncbi.nlm.nih.gov/pubmed/35259016
http://dx.doi.org/10.1073/pnas.2121609119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931323/
https://www.ncbi.nlm.nih.gov/pubmed/35259016
http://dx.doi.org/10.1073/pnas.2121609119

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