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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration
Neurodegenerative diseases affect a rapidly growing number of the aging population globally. These conditions have proven extremely difficult to treat due to our limited understanding of their mechanisms, but they are characterized by protein aggregation, inflammation, lysosomal dysfunction, and neu...
Autores principales: | Vest, Ryan T., Chou, Ching-Chieh, Zhang, Hui, Haney, Michael S., Li, Lulin, Laqtom, Nouf N., Chang, Betty, Shuken, Steven, Nguyen, Andy, Yerra, Lakshmi, Yang, Andrew C., Green, Carol, Tanga, Mary, Abu-Remaileh, Monther, Bassik, Michael C., Frydman, Judith, Luo, Jian, Wyss-Coray, Tony |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931323/ https://www.ncbi.nlm.nih.gov/pubmed/35259016 http://dx.doi.org/10.1073/pnas.2121609119 |
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