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Ferroptosis regulation by the NGLY1/NFE2L1 pathway

Ferroptosis is an oxidative form of nonapoptotic cell death whose transcriptional regulation is poorly understood. Cap’n’collar (CNC) transcription factors including nuclear factor erythroid-2–related factor 1 (NFE2L1/NRF1) and NFE2L2 (NRF2) are important regulators of oxidative stress responses. NF...

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Detalles Bibliográficos
Autores principales: Forcina, Giovanni C., Pope, Lauren, Murray, Magdalena, Dong, Wentao, Abu-Remaileh, Monther, Bertozzi, Carolyn R., Dixon, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931371/
https://www.ncbi.nlm.nih.gov/pubmed/35271393
http://dx.doi.org/10.1073/pnas.2118646119