Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs

The phosphorylated RNA polymerase II CTD interacting factor 1 (PCIF1) is a methyltransferase that adds a methyl group to the N6-position of 2′O-methyladenosine (A(m)), generating N6, 2′O-dimethyladenosine (m(6)A(m)) when A(m) is the cap-proximal nucleotide. In addition, PCIF1 has ancillary methylati...

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Detalles Bibliográficos
Autores principales: Yu, Dan, Dai, Nan, Wolf, Eric J., Corrêa, Ivan R., Zhou, Jujun, Wu, Tao, Blumenthal, Robert M., Zhang, Xing, Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931429/
https://www.ncbi.nlm.nih.gov/pubmed/35189146
http://dx.doi.org/10.1016/j.jbc.2022.101751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931429/
https://www.ncbi.nlm.nih.gov/pubmed/35189146
http://dx.doi.org/10.1016/j.jbc.2022.101751

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