Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma

SWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple “-omics” methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have fun...

Descripción completa

Detalles Bibliográficos
Autores principales: Peinado, Paola, Andrades, Alvaro, Cuadros, Marta, Rodriguez, Maria Isabel, Coira, Isabel F., Garcia, Daniel J., Benitez-Cantos, Maria S., Cano, Carlos, Zarzuela, Eduardo, Muñoz, Javier, Loidi, Claudia, Saiz, Monica, Medina, Pedro P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931969/
https://www.ncbi.nlm.nih.gov/pubmed/35300733
http://dx.doi.org/10.1186/s13148-022-01261-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931969/
https://www.ncbi.nlm.nih.gov/pubmed/35300733
http://dx.doi.org/10.1186/s13148-022-01261-3

Ejemplares similares