BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting super-enhancers in neuroblastoma

BACKGROUND: Neuroblastoma (NB) is a common extracranial malignancy with high mortality in children. Recently, super-enhancers (SEs) have been reported to play a critical role in the tumorigenesis and development of NB via regulating a wide range of oncogenes Thus, the synthesis and identification of...

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Detalles Bibliográficos
Autores principales: Chen, Yan-Ling, Li, Xiao-Lu, Li, Gen, Tao, Yan-Fang, Zhuo, Ran, Cao, Hai-Bo, Jiao, Wan-yan, Li, Zhi-Heng, Zhu, Zhen-Hong, Fang, Fang, Xie, Yi, Liao, Xin-Mei, Wu, Di, Wang, Hai-Rong, Yu, Juan-Juan, Jia, Si-Qi, Yang, Yang, Feng, Chen-Xi, Yang, Peng-Cheng, Fei, Xiao-Dong, Wang, Jian-Wei, Xu, Yun-Yun, Qian, Guang-Hui, Zhang, Zi-Mu, Pan, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932231/
https://www.ncbi.nlm.nih.gov/pubmed/35303940
http://dx.doi.org/10.1186/s13578-022-00769-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932231/
https://www.ncbi.nlm.nih.gov/pubmed/35303940
http://dx.doi.org/10.1186/s13578-022-00769-8

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