STAT3 inhibitor Napabucasin abrogates MDSC immunosuppressive capacity and prolongs survival of melanoma-bearing mice

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) represent a negative prognostic factor in malignant melanoma. These cells are generated under chronic inflammatory conditions typical of cancer. The transcription factor signal transducer and activator of transcription 3 (STAT3) orchestrates MDSC...

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Detalles Bibliográficos
Autores principales: Bitsch, Rebekka, Kurzay, Annina, Özbay Kurt, Feyza, De La Torre, Carolina, Lasser, Samantha, Lepper, Alisa, Siebenmorgen, Alina, Müller, Verena, Altevogt, Peter, Utikal, Jochen, Umansky, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932276/
https://www.ncbi.nlm.nih.gov/pubmed/35301236
http://dx.doi.org/10.1136/jitc-2021-004384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932276/
https://www.ncbi.nlm.nih.gov/pubmed/35301236
http://dx.doi.org/10.1136/jitc-2021-004384

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