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Neuronal endolysosomal transport and lysosomal functionality in maintaining axonostasis

Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos, which is essential for neuron function and survival. Deficits in lysosome function result in progressive neurodegeneration in most lysosomal storage disorders and contribute to the pathogenesis of aging-related...

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Detalles Bibliográficos
Autores principales: Roney, Joseph C., Cheng, Xiu-Tang, Sheng, Zu-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932522/
https://www.ncbi.nlm.nih.gov/pubmed/35142819
http://dx.doi.org/10.1083/jcb.202111077