TIRAP drives myelosuppression through an Ifnγ–Hmgb1 axis that disrupts the endothelial niche in mice

Inflammation is associated with bone marrow failure syndromes, but how specific molecules impact the bone marrow microenvironment is not well elucidated. We report a novel role for the miR-145 target, Toll/interleukin-1 receptor domain containing adaptor protein (TIRAP), in driving bone marrow failu...

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Detalles Bibliográficos
Autores principales: Gopal, Aparna, Ibrahim, Rawa, Fuller, Megan, Umlandt, Patricia, Parker, Jeremy, Tran, Jessica, Chang, Linda, Wegrzyn-Woltosz, Joanna, Lam, Jeffrey, Li, Jenny, Lu, Melody, Karsan, Aly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932532/
https://www.ncbi.nlm.nih.gov/pubmed/35089323
http://dx.doi.org/10.1084/jem.20200731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932532/
https://www.ncbi.nlm.nih.gov/pubmed/35089323
http://dx.doi.org/10.1084/jem.20200731

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