Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytosis across the BBB. Here, we characterized the pharma...

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Detalles Bibliográficos
Autores principales: Arguello, Annie, Mahon, Cathal S., Calvert, Meredith E.K., Chan, Darren, Dugas, Jason C., Pizzo, Michelle E., Thomsen, Elliot R., Chau, Roni, Damo, Lorna A., Duque, Joseph, Fang, Meng, Giese, Tina, Kim, Do Jin, Liang, Nicholas, Nguyen, Hoang N., Solanoy, Hilda, Tsogtbaatar, Buyankhishig, Ullman, Julie C., Wang, Junhua, Dennis, Mark S., Diaz, Dolores, Gunasekaran, Kannan, Henne, Kirk R., Lewcock, Joseph W., Sanchez, Pascal E., Troyer, Matthew D., Harris, Jeffrey M., Scearce-Levie, Kimberly, Shan, Lu, Watts, Ryan J., Thorne, Robert G., Henry, Anastasia G., Kariolis, Mihalis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932535/
https://www.ncbi.nlm.nih.gov/pubmed/35226042
http://dx.doi.org/10.1084/jem.20211057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932535/
https://www.ncbi.nlm.nih.gov/pubmed/35226042
http://dx.doi.org/10.1084/jem.20211057

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