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Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration

Accumulation of tau has been implicated in various neurodegenerative diseases termed tauopathies. Tau is a microtubule-associated protein but is also actively released into the extracellular fluids including brain interstitial fluid and cerebrospinal fluid (CSF). However, it remains elusive whether...

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Detalles Bibliográficos
Autores principales: Ishida, Kazuhisa, Yamada, Kaoru, Nishiyama, Risa, Hashimoto, Tadafumi, Nishida, Itaru, Abe, Yoichiro, Yasui, Masato, Iwatsubo, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932543/
https://www.ncbi.nlm.nih.gov/pubmed/35212707
http://dx.doi.org/10.1084/jem.20211275