CRISPR-Cas9 approach confirms Calcineurin-responsive zinc finger 1 (Crz1) transcription factor as a promising therapeutic target in echinocandin-resistant Candida glabrata

Invasive fungal infections, which kill more than 1.6 million patients each year worldwide, are difficult to treat due to the limited number of antifungal drugs (azoles, echinocandins, and polyenes) and the emergence of antifungal resistance. The transcription factor Crz1, a key regulator of cellular...

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Detalles Bibliográficos
Autores principales: Ceballos-Garzon, Andres, Roman, Elvira, Pla, Jesús, Pagniez, Fabrice, Amado, Daniela, Alméciga-Díaz, Carlos J., Le Pape, Patrice, Parra-Giraldo, Claudia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932611/
https://www.ncbi.nlm.nih.gov/pubmed/35303047
http://dx.doi.org/10.1371/journal.pone.0265777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932611/
https://www.ncbi.nlm.nih.gov/pubmed/35303047
http://dx.doi.org/10.1371/journal.pone.0265777

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