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Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients
Dysregulation of mitochondrial Ca(2+) homeostasis has been linked to neurodegenerative diseases. Mitochondrial Ca(2+) uptake is mediated via the calcium uniporter complex that is primarily regulated by MICU1, a Ca(2+)-sensing gatekeeper. Recently, human patients with MICU1 loss-of-function mutations...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932652/ https://www.ncbi.nlm.nih.gov/pubmed/35302860 http://dx.doi.org/10.1126/sciadv.abj4716 |