Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients

Dysregulation of mitochondrial Ca(2+) homeostasis has been linked to neurodegenerative diseases. Mitochondrial Ca(2+) uptake is mediated via the calcium uniporter complex that is primarily regulated by MICU1, a Ca(2+)-sensing gatekeeper. Recently, human patients with MICU1 loss-of-function mutations...

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Detalles Bibliográficos
Autores principales: Singh, Raghavendra, Bartok, Adam, Paillard, Melanie, Tyburski, Ashley, Elliott, Melanie, Hajnóczky, György
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932652/
https://www.ncbi.nlm.nih.gov/pubmed/35302860
http://dx.doi.org/10.1126/sciadv.abj4716

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