Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration

Rod and cone photoreceptors degenerate in retinitis pigmentosa (RP). While downstream neurons survive, they undergo physiological changes, including accelerated spontaneous firing in retinal ganglion cells (RGCs). Retinoic acid (RA) is the molecular trigger of RGC hyperactivity, but whether this int...

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Detalles Bibliográficos
Autores principales: Telias, Michael, Sit, Kevin K., Frozenfar, Daniel, Smith, Benjamin, Misra, Arjit, Goard, Michael J., Kramer, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932665/
https://www.ncbi.nlm.nih.gov/pubmed/35302843
http://dx.doi.org/10.1126/sciadv.abm4643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8932665/
https://www.ncbi.nlm.nih.gov/pubmed/35302843
http://dx.doi.org/10.1126/sciadv.abm4643

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