The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function

Ribosomal Protein (Rp) gene haploinsufficiency affects translation rate, can lead to protein aggregation, and causes cell elimination by competition with wild type cells in mosaic tissues. We find that the modest changes in ribosomal subunit levels observed were insufficient for these effects, which...

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Detalles Bibliográficos
Autores principales: Kiparaki, Marianthi, Khan, Chaitali, Folgado-Marco, Virginia, Chuen, Jacky, Moulos, Panagiotis, Baker, Nicholas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933008/
https://www.ncbi.nlm.nih.gov/pubmed/35179490
http://dx.doi.org/10.7554/eLife.71705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933008/
https://www.ncbi.nlm.nih.gov/pubmed/35179490
http://dx.doi.org/10.7554/eLife.71705

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