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The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function
Ribosomal Protein (Rp) gene haploinsufficiency affects translation rate, can lead to protein aggregation, and causes cell elimination by competition with wild type cells in mosaic tissues. We find that the modest changes in ribosomal subunit levels observed were insufficient for these effects, which...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933008/ https://www.ncbi.nlm.nih.gov/pubmed/35179490 http://dx.doi.org/10.7554/eLife.71705 |