Development of applicable thiol-linked antibody–drug conjugates with improved stability and therapeutic index

Maleimides are typically applicable for coupling with reactive thiol moieties of antibodies in antibody–drug conjugates (ADCs) via the thiol-Michael click chemistry. Even so, the thiosuccinimide group produced in ADCs is unstable under physiological conditions, which is a unresolved issue in the ADC...

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Detalles Bibliográficos
Autores principales: Wang, Yanming, Xie, Fei, Liu, Lianqi, Xu, Xin, Fan, Shiyong, Zhong, Wu, Zhou, Xinbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933021/
https://www.ncbi.nlm.nih.gov/pubmed/35244495
http://dx.doi.org/10.1080/10717544.2022.2039807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933021/
https://www.ncbi.nlm.nih.gov/pubmed/35244495
http://dx.doi.org/10.1080/10717544.2022.2039807

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