BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study

Intervertebral disc degeneration (IDD) is the most common chronic skeletal muscle degeneration disease. Although the underlying mechanisms remain unclear, nucleus pulposus (NP) autophagy, senescence, and apoptosis are known to play a critical role in this process. Previous studies suggest that bromo...

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Detalles Bibliográficos
Autores principales: Zhang, Guang-Zhi, Chen, Hai-Wei, Deng, Ya-jun, Liu, Ming-Qiang, Wu, Zuo-Long, Ma, Zhan-Jun, He, Xue-Gang, Gao, Yi-Cheng, Kang, Xue-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933081/
https://www.ncbi.nlm.nih.gov/pubmed/35308165
http://dx.doi.org/10.1155/2022/9181412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933081/
https://www.ncbi.nlm.nih.gov/pubmed/35308165
http://dx.doi.org/10.1155/2022/9181412

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