Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth

EGLN3 is critically important for growth of various cancers including lung cancer. However, virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in cancers. EGLN3 catalyzes the hydroxylation of extracellular signal-regulated kinase 3 (Erk3), a potent driver of cance...

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Detalles Bibliográficos
Autores principales: Jin, Ying, Pan, Yamu, Zheng, Shuang, Liu, Yao, Xu, Jie, Peng, Yazhi, Zhang, Zemei, Wang, Yadong, Xiong, Yulian, Xu, Lei, Mu, Kaiyu, Chen, Suwen, Zheng, Fei, Yuan, Ye, Fu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933280/
https://www.ncbi.nlm.nih.gov/pubmed/35124697
http://dx.doi.org/10.1038/s41388-022-02203-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933280/
https://www.ncbi.nlm.nih.gov/pubmed/35124697
http://dx.doi.org/10.1038/s41388-022-02203-2

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