Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion

Dysregulated glucagon secretion from pancreatic alpha-cells is a key feature of type-1 and type-2 diabetes (T1D and T2D), yet our mechanistic understanding of alpha-cell function is underdeveloped relative to insulin-secreting beta-cells. Here we show that the enzyme acetyl-CoA-carboxylase 1 (ACC1),...

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Detalles Bibliográficos
Autores principales: Veprik, Anna, Denwood, Geoffrey, Liu, Dong, Bany Bakar, Rula, Morfin, Valentin, McHugh, Kara, Tebeka, Nchimunya N., Vetterli, Laurène, Yonova-Doing, Ekaterina, Gribble, Fiona, Reimann, Frank, Hoehn, Kyle L., Hemsley, Piers A., Ahnfelt-Rønne, Jonas, Rorsman, Patrik, Zhang, Quan, de Wet, Heidi, Cantley, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933412/
https://www.ncbi.nlm.nih.gov/pubmed/35304577
http://dx.doi.org/10.1038/s42003-022-03170-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933412/
https://www.ncbi.nlm.nih.gov/pubmed/35304577
http://dx.doi.org/10.1038/s42003-022-03170-w

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