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WTAP-mediated m(6)A modification of lncRNA NORAD promotes intervertebral disc degeneration

N6-methyladenosine (m(6)A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes. However, the underlying mechanism of m(6)A regulation in intervertebral disc degeneration (IVDD) remains elusive. Here, we show that methylation...

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Detalles Bibliográficos
Autores principales: Li, Gaocai, Ma, Liang, He, Shujie, Luo, Rongjin, Wang, Bingjin, Zhang, Weifeng, Song, Yu, Liao, Zhiwei, Ke, Wencan, Xiang, Qian, Feng, Xiaobo, Wu, Xinghuo, Zhang, Yukun, Wang, Kun, Yang, Cao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933458/
https://www.ncbi.nlm.nih.gov/pubmed/35304463
http://dx.doi.org/10.1038/s41467-022-28990-6