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Optimization of an O(2)-balanced bioartificial pancreas for type 1 diabetes using statistical design of experiment
A bioartificial pancreas (BAP) encapsulating high pancreatic islets concentration is a promising alternative for type 1 diabetes therapy. However, the main limitation of this approach is O(2) supply, especially until graft neovascularization. Here, we described a methodology to design an optimal O(2...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933496/ https://www.ncbi.nlm.nih.gov/pubmed/35304495 http://dx.doi.org/10.1038/s41598-022-07887-w |