A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats

Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into host chromosomal DNA. HIV-1 integration sites are highly biased towards actively transcribed genes, likely mediated by binding of the IN protein to specific host factors, particularly LEDGF, located at...

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Detalles Bibliográficos
Autores principales: Winans, Shelby, Yu, Hyun Jae, de los Santos, Kenia, Wang, Gary Z., KewalRamani, Vineet N., Goff, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933506/
https://www.ncbi.nlm.nih.gov/pubmed/35304442
http://dx.doi.org/10.1038/s41467-022-29097-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933506/
https://www.ncbi.nlm.nih.gov/pubmed/35304442
http://dx.doi.org/10.1038/s41467-022-29097-8

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