CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element

The epigenetic patterns that are established during early thymic development might determine mature T cell physiology and function, but the molecular basis and topography of the genetic elements involved are not fully known. Here we show, using the Cd4 locus as a paradigm for early developmental pro...

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Detalles Bibliográficos
Autores principales: Teghanemt, Athmane, Pulipati, Priyanjali, Misel-Wuchter, Kara, Day, Kenneth, Yorek, Matthew S., Yi, Ren, Keen, Henry L., Au, Christy, Maretzky, Thorsten, Gurung, Prajwal, Littman, Dan R., Issuree, Priya D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933563/
https://www.ncbi.nlm.nih.gov/pubmed/35304452
http://dx.doi.org/10.1038/s41467-022-28914-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933563/
https://www.ncbi.nlm.nih.gov/pubmed/35304452
http://dx.doi.org/10.1038/s41467-022-28914-4

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