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CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element
The epigenetic patterns that are established during early thymic development might determine mature T cell physiology and function, but the molecular basis and topography of the genetic elements involved are not fully known. Here we show, using the Cd4 locus as a paradigm for early developmental pro...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933563/ https://www.ncbi.nlm.nih.gov/pubmed/35304452 http://dx.doi.org/10.1038/s41467-022-28914-4 |