Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors

Reinvigoration of antitumor immunity has recently become the central theme for the development of cancer therapies. Nevertheless, the precise delivery of immunotherapeutic activities to the tumors remains challenging. Here, we explore a synthetic gene circuit-based strategy for specific tumor identi...

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Detalles Bibliográficos
Autores principales: Wang, Yafeng, Zhang, Guiquan, Meng, Qingzhou, Huang, Shisheng, Guo, Panpan, Leng, Qibin, Sun, Lingyun, Liu, Geng, Huang, Xingxu, Liu, Jianghuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933567/
https://www.ncbi.nlm.nih.gov/pubmed/35304449
http://dx.doi.org/10.1038/s41467-022-29120-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933567/
https://www.ncbi.nlm.nih.gov/pubmed/35304449
http://dx.doi.org/10.1038/s41467-022-29120-y

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