Genetic or siRNA inhibition of MBD2 attenuates the UUO- and I/R-induced renal fibrosis via downregulation of EGR1

DNA methylation plays a pivotal role in the progression of renal fibrosis. Methyl-CpG–binding domain protein 2 (MBD2), a protein reader of methylation, is involved in the development of acute kidney injury (AKI) caused by vancomycin. However, the role and mechanism of action of MBD2 in renal remain...

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Detalles Bibliográficos
Autores principales: Ai, Kai, Li, Xiaozhou, Zhang, Pan, Pan, Jian, Li, Huiling, He, Zhibiao, Zhang, Hongliang, Yi, Lei, Kang, Ye, Wang, Yinhuai, Chen, Junxiang, Li, Yijian, Xiang, Xudong, Chai, Xiangping, Zhang, Dongshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933641/
https://www.ncbi.nlm.nih.gov/pubmed/35356685
http://dx.doi.org/10.1016/j.omtn.2022.02.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933641/
https://www.ncbi.nlm.nih.gov/pubmed/35356685
http://dx.doi.org/10.1016/j.omtn.2022.02.015

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