Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knockout mice have identified focal, canonical hypomethylation ph...

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Detalles Bibliográficos
Autores principales: Smith, Amanda M., Verdoni, Angela M., Abel, Haley J., Chen, David Y., Ketkar, Shamika, Leight, Elizabeth R., Miller, Christopher A., Ley, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933692/
https://www.ncbi.nlm.nih.gov/pubmed/35313694
http://dx.doi.org/10.1016/j.isci.2022.104004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933692/
https://www.ncbi.nlm.nih.gov/pubmed/35313694
http://dx.doi.org/10.1016/j.isci.2022.104004

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