Cargando…

Somatic Dnmt3a inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells

Mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) are the most common cause of clonal hematopoiesis and are among the most common initiating events of acute myeloid leukemia (AML). Studies in germline and somatic Dnmt3a knockout mice have identified focal, canonical hypomethylation ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smith, Amanda M., Verdoni, Angela M., Abel, Haley J., Chen, David Y., Ketkar, Shamika, Leight, Elizabeth R., Miller, Christopher A., Ley, Timothy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933692/ https://www.ncbi.nlm.nih.gov/pubmed/35313694 http://dx.doi.org/10.1016/j.isci.2022.104004

Ejemplares similares

Remethylation of Dnmt3a(−/−) hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing
por: Ketkar, Shamika, et al.
Publicado: (2020)

Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype
por: Chen, David Y., et al.
Publicado: (2021)

Slowed canonical progress in large fields of science
por: Chu, Johan S. G., et al.
Publicado: (2021)

DNMT1 Maintains Progenitor Function in Self-Renewing Somatic Tissue
por: Sen, George L., et al.
Publicado: (2010)

High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells
por: Famili, Farbod, et al.
Publicado: (2016)

It's spring-time for slow inactivation
por: Olcese, Riccardo
Publicado: (2009)

TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers
por: Charlton, Jocelyn, et al.
Publicado: (2020)

Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome
por: Smith, Amanda M., et al.
Publicado: (2021)

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
por: Jeong, Mira, et al.
Publicado: (2018)

High Canonical Wnt/β-Catenin Activity Sensitizes Murine Hematopoietic Stem and Progenitor Cells to DNA Damage
por: Wang, Yiting, et al.
Publicado: (2019)

Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis
por: Gong, Eun Ji, et al.
Publicado: (2014)

Preimplantation expression of the somatic form of Dnmt1 suggests a role in the inheritance of genomic imprints
por: Cirio, M Cecilia, et al.
Publicado: (2008)

Measurable residual disease of canonical versus non-canonical DNMT3A, TET2, or ASXL1 mutations in AML at stem cell transplantation
por: Jentzsch, Madlen, et al.
Publicado: (2021)

DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders
por: Sato, Hanae, et al.
Publicado: (2016)

Hematopoietic Origin of Murine Lung Fibroblasts
por: McDonald, Lindsay T., et al.
Publicado: (2015)

Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
por: An, Ping, et al.
Publicado: (2009)

Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages
por: Yan, Jinglian, et al.
Publicado: (2018)

Slow Poisoning by Lead
Publicado: (1851)

Progress in understanding slow inactivation speeds up
por: Payandeh, Jian
Publicado: (2018)

Kv1 channel inactivation: Slow and slower
por: Short, Ben
Publicado: (2022)

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer
por: Feng, Yang, et al.
Publicado: (2023)

Donor T cell DNMT3a regulates alloreactivity in mouse models of hematopoietic stem cell transplantation
por: Ktena, Yiouli P., et al.
Publicado: (2022)

Melanoma in a patient with DNMT3A overgrowth syndrome
por: Chen, David Y., et al.
Publicado: (2023)

Loss of DNMT1o Disrupts Imprinted X Chromosome Inactivation and Accentuates Placental Defects in Females
por: McGraw, Serge, et al.
Publicado: (2013)

Slow sodium-channel inactivation underlies spike threshold variability
por: Harrison, Paul M, et al.
Publicado: (2013)

DNMT3a-dermatopontin axis suppresses breast cancer malignancy via inactivating YAP
por: Ye, Danrong, et al.
Publicado: (2023)

DNMT1 mutations leading to neurodegeneration paradoxically reflect on mitochondrial metabolism
por: Maresca, Alessandra, et al.
Publicado: (2020)

Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice
por: Sasaki, Keisuke, et al.
Publicado: (2019)

Incorporation of non-canonical amino acids into the developing murine proteome
por: Calve, Sarah, et al.
Publicado: (2016)

DNMT3A(R882)-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A(R882C) OCI-AML3 leukemia cell line
por: Chen, David, et al.
Publicado: (2018)

Dnmt3a Regulates Myeloproliferation and Liver-Specific Expansion of Hematopoietic Stem and Progenitor Cells
por: Guryanova, Olga A., et al.
Publicado: (2015)

Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
por: Ostrander, Elizabeth L., et al.
Publicado: (2020)

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
por: Liao, Jing, et al.
Publicado: (2015)

Role of Domain 4 in Sodium Channel Slow Inactivation
por: Mitrovic, Nenad, et al.
Publicado: (2000)

Fishery-Induced Selection for Slow Somatic Growth in European Eel
por: Bevacqua, Daniele, et al.
Publicado: (2012)

Germline mutations and somatic inactivation of TRIM28 in Wilms tumour
por: Halliday, Benjamin J., et al.
Publicado: (2018)

Deep sequencing of small RNAs identifies canonical and non-canonical miRNA and endogenous siRNAs in mammalian somatic tissues
por: Castellano, Leandro, et al.
Publicado: (2013)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB signaling
por: Ortega, Michael A., et al.
Publicado: (2022)

Constitutive Activation of the Canonical NF-κB Pathway Leads to Bone Marrow Failure and Induction of Erythroid Signature in Hematopoietic Stem Cells
por: Nakagawa, Masahiro Marshall, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_s4qtjm41up3v41fq4ke01ev9sl