Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

DEPTOR is a 48 kDa protein upregulated in multiple myeloma (MM) cells. DEPTOR inhibits mTOR and, by repressing a negative feedback loop, promotes AKT activation. We previously identified a compound that binds to DEPTOR in MM cells and induces its proteasomal degradation. To identify the mechanism of...

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Detalles Bibliográficos
Autores principales: Vega, Mario, Chen, Yu, Shi, Yijiang, Gera, Joseph, Lichtenstein, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933699/
https://www.ncbi.nlm.nih.gov/pubmed/35216969
http://dx.doi.org/10.1016/j.jbc.2022.101750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8933699/
https://www.ncbi.nlm.nih.gov/pubmed/35216969
http://dx.doi.org/10.1016/j.jbc.2022.101750

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